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Objective To investigate the change in mortality of congenital malformation in children aged ＜5 years in Beijing from 2006 to 2015.Methods Using the death surveillance data in children aged ＜5 years in Beijing from 2006 to 2015,which was collected from the real-time surveillance network,we calculated the area and age distributions of the mortality of congenital malformation in children aged ＜5 years in Beijing.Meanwhile,the variations of age,time and space in the causes of deaths were discussed.Results The mortality rate of congenital malformation in the children s decreased from 1.909‰ in 2006 to 0.703‰ in 2015,the decrease rate was 63.17％.The decrease rate was highest in neonates (71.50％) (x2=57.993,P＜0.01).Expect urban area (x2=3.384,P＞0.05),the mortality rates of congenital malformation in the children showed a downward trend in outer suburban area and suburban area (x2=40.637 and 50.646,P＜0.01).The proportion of the children died of congenital malformation decreased from 32.97％ in 2006 to 23.24％ in 2015,which mainly occurred in infancy and neonatal period (x2=9.395 and 4.354,P＜0.05).The constituent ratios of the children died of neural tube defects,respiratory system abnormalities and other abnormalities decreased significantly (x2=13.478,7.358,7.912 and 10.074,P＜0.01).The constituent ratios of children died of chromosomal abnormality,multiple malformations and digestive tract abnormality didn't decreased significantly (P＞0.05).In the leading causes of deaths from congenital malformation,the mortality of congenital heart disease,neural tube defects and digestive tract atresia decreased obviously (x2=70.868,18.431 and 9.225,P＜0.01),except biliary atresia (x2=1.407,P＞ 0.05).There was an obvious area specific difference between the deaths of congenital heart disease and the deaths of neural tube defects,the mortality was higher in outer suburbs than in suburban and urban area (x2=45.783 and 6.649,P＜0.05).Conclusion Although the mortality rate of children with congenital malformation in Beijing has declined year by year,it is still the main cause of deaths in children under 5 years old,and the prevention and control of related diseases should be strengthened.
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Objective To investigate the change in mortality of congenital malformation in children aged ＜5 years in Beijing from 2006 to 2015.Methods Using the death surveillance data in children aged ＜5 years in Beijing from 2006 to 2015,which was collected from the real-time surveillance network,we calculated the area and age distributions of the mortality of congenital malformation in children aged ＜5 years in Beijing.Meanwhile,the variations of age,time and space in the causes of deaths were discussed.Results The mortality rate of congenital malformation in the children s decreased from 1.909‰ in 2006 to 0.703‰ in 2015,the decrease rate was 63.17％.The decrease rate was highest in neonates (71.50％) (x2=57.993,P＜0.01).Expect urban area (x2=3.384,P＞0.05),the mortality rates of congenital malformation in the children showed a downward trend in outer suburban area and suburban area (x2=40.637 and 50.646,P＜0.01).The proportion of the children died of congenital malformation decreased from 32.97％ in 2006 to 23.24％ in 2015,which mainly occurred in infancy and neonatal period (x2=9.395 and 4.354,P＜0.05).The constituent ratios of the children died of neural tube defects,respiratory system abnormalities and other abnormalities decreased significantly (x2=13.478,7.358,7.912 and 10.074,P＜0.01).The constituent ratios of children died of chromosomal abnormality,multiple malformations and digestive tract abnormality didn't decreased significantly (P＞0.05).In the leading causes of deaths from congenital malformation,the mortality of congenital heart disease,neural tube defects and digestive tract atresia decreased obviously (x2=70.868,18.431 and 9.225,P＜0.01),except biliary atresia (x2=1.407,P＞ 0.05).There was an obvious area specific difference between the deaths of congenital heart disease and the deaths of neural tube defects,the mortality was higher in outer suburbs than in suburban and urban area (x2=45.783 and 6.649,P＜0.05).Conclusion Although the mortality rate of children with congenital malformation in Beijing has declined year by year,it is still the main cause of deaths in children under 5 years old,and the prevention and control of related diseases should be strengthened.
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background: Percutaneous septal ablation is a therapeutic option for patients with obstructive hypertrophic cardiomyopathy refrac-tory to optimal medical therapy. However, results of initial persistence and long-term safety are still controversial. Objectives: The aim of this study was to report percutaneous alcohol septal ablation technique, clinical and functional outcome, cardiovascular events and its impact on long-term follow-up. Methods: A total of 23 patients were included in the study. Functional class (FC), left ventricular outflow tract gradient before and after the procedure and long-term cardiovascular events were evaluated. results: Median follow-up was 52 months (IR 33-72). All patients were in FC III or IV prior to the procedure, under maximum tolerated medical therapy. The procedure was successful in 91% of cases, with 85% of patients currently in FC I and 15% in FC II. Baseline left ventricular outflow tract gradient decreased from 75 mmHg (95% CI 51-89) to 25 mmHg (95% CI 10-37) (p <0.003) and with Valsalva maneuver from 118 mmHg (95% CI 88-152) to 38 mmHg (95% CI 16-69) (p <0.0002), persisting in the long-term follow-up. During hospitalization, two patients presented with complete atrioventricular block requiring permanent pacemaker implantation. No cardiovascular deaths occurred during follow up. Conclusions: Alcohol septal ablation is a promising option for the treatment of a selected population with hypertrophic obstructive cardiomyopathy, generating sustained clinical and functional improvement with low incidence of events in the long-term follow up.
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Objective To analyze the disease burden caused by low body weight in children under 5 years old in China from 1990 to 2010.Methods The analysis was conducted on the low body weight related deaths, years lived with disability(YLD), years of life lost (YLL) and disability-adjusted life years (DALY) in children aged ＜5 years in China from 1990 to 2010 by using the data for the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD2010).The annual low body weight related deaths, YLL, YLD and DALY from 1990 to 2010 were compared.Results Among the children aged ＜5 years, 2 271 deaths and 295 300 person-years DALY were attributable to low body weight in 2010.Compared with 1990, the number of deaths and DALY attributed to low body weight decreased by 96.75％ and 95.46％ respectively.In 2010, the YLD and YLL attributable to low body weight in the children aged ＜ 5 years were 101 500 person-years and 193 800 person-years respectively.Compared with 1990, the YLD and YLL caused by low body weight in the children aged ＜5 years declined by 444 800 and 5.76 million person-years respectively.Conclusion Compared with 1990, the death and DALY, YLD and YLL attributable to low body weight in the children aged ＜5 years significantly declined in 2010.Considering the serious impact of death to loss of life in young age group, the effects and burden of disease caused by low body weight in the children aged ＜ 5 years should not be neglected in China.
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Blastomeres; Serum; Pathological Conditions, Anatomical; Chorionic Gonadotropin The group 1 of 75 cases of post molar evacuation and the group 2 of 292 cases of gestational trophoblastic tumors (GTT) were followed up until beta-hCG level serum, determined by IMX, reaches the threshold of < 5 IU/l, there was not any complication after 2 years. There were 7.5% recurrents cases in GTT group, in some cases, beta-hCG reaches 0 UI/l. In the recurrent group, the rate of resistance to the treatment got to 40%, and the rate of resistance to single chemotherapy by MTX got to 30%. 50% of recurrent patients have had uterine histological exams with 36% choriocarcinoma, 4.5% invasive molar